The Impact of DTYMK as a Prognostic Marker in Colorectal Cancer.

ABSTRACT:

Background

Overexpression of deoxythymidylate kinase (DTYMK) has been associated with more aggressiveness and pathological behaviors in hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC). However, the expression of DTYMK and its prognostic significance in colorectal cancer (CRC) patients are yet unknown. The goal of this study was to investigate the DTYMK immunohistochemistry reactivity in CRC tissues and to see how it correlated with various histological and clinical features as well as survival.

Methods

Several bioinformatics databases and two tissue microarrays (TMAs) of 227 cases were used in this study. Immunohistochemistry assay was used to study the protein expression of DTYMK.

Results

Based on the GEPIA, UALCAN, and Oncomine databases, DTYMK

SUBMITTER: Aloliqi AA 

PROVIDER: S-EPMC9990730 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature