Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study.

ABSTRACT:

Background

Apolipoprotein E gene (APOE) ε4 allele is associated with a higher risk of carotid atherosclerosis, but less is known about the association of APOE with intracranial atherosclerotic disease (IAD). We aimed to investigate the association of APOE alleles with IAD in a cross-sectional autopsy study.

Methods

We measured the stenosis in the 12 arteries of the Circle of Willis using postmortem morphometric measurements. The APOE polymorphism was determined by real-time polymerase chain reaction. We assessed the association between APOE polymorphism and IAD using regression models adjusted for sociodemographic and clinical variables. We also verified the modifier effect of age, sex, and race on this association. We stratified the analysis by age group to investigate the

SUBMITTER: Paradela RS 

PROVIDER: S-EPMC9990746 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature