Identification of potential therapeutic intervening targets by in-silico analysis of nsSNPs in preterm birth-related genes.

ABSTRACT: Prematurity is the foremost cause of death in children under 5 years of age. Genetics contributes to 25-40% of all preterm births (PTB) yet we still need to identify specific targets for intervention based on genetic pathways. This study involved the effect of region-specific non-synonymous variations and their transcript level mutational impact on protein functioning and stability by various in-silico tools. This investigation identifies potential therapeutic targets to manage the challenge of PTB, corresponding protein cavities and explores their binding interactions with intervening compounds. We searched 20 genes coding 55 PTB proteins from NCBI. Single Nucleotide Polymorphisms (SNPs) of concerned genes were extracted from ENSEMBL, and filtration of exonic variants (non-synonymous) was

SUBMITTER: Azmi MB 

PROVIDER: S-EPMC9990928 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature