Hepatotoxicity in immune checkpoint inhibitors: A pharmacovigilance study from 2014–2021

ABSTRACT: Adverse events(AEs) related to hepatotoxicity have been reported in patients treated with immune checkpoint inhibitors (ICIs). As the number of adverse events increases, it is necessary to assess the differences in each immune checkpoint inhibitor regimen. The purpose of this study was to examine the relationship between ICIs and hepatotoxicity in a scientific and systematic manner. Data were obtained from the FDA Adverse Event Reporting System database (FAERS) and included data from the first quarter of 2014 to the fourth quarter of 2021. Disproportionality analysis assessed the association between drugs and adverse reactions based on the reporting odds ratio (ROR) and information components (IC). 9,806 liver adverse events were reported in the FAERS database. A strong signal was detected

SUBMITTER: Xu Z 

PROVIDER: S-EPMC9990950 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature