Weight loss, visit-to-visit body weight variability and cognitive function in older individuals.

ABSTRACT:

Objective

to investigate the association between variability and loss of body weight with subsequent cognitive performance and activities of daily living in older individuals.

Design

cross-sectional cohort study.

Setting

PROspective Study of Pravastatin in the Elderly at Risk, multicentre trial with participants from Scotland, Ireland and the Netherlands.

Subjects

4,309 participants without severe cognitive dysfunction (mean age 75.1 years, standard deviation (SD) = 3.3), at higher risk for cardiovascular disease (CVD).

Methods

body weight was measured every 3 months for 2.5 years. Weight loss was defined as an average slope across all weight measurements and as ≥5% decrease in baseline body weight during follow-up. Visit-to-visit variability was defined

SUBMITTER: Zonneveld MH 

PROVIDER: S-EPMC9990986 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature