The landscape of m¹A modification and its posttranscriptional regulatory functions in primary neurons.

ABSTRACT: Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases. N1-methyladenosine (m¹A) is an RNA modification that can affect gene expression and RNA stability. The m¹A landscape and potential functions of m¹A modification in neurons remain poorly understood. We explored RNA (mRNA, lncRNA, and circRNA) m¹A modification in normal and OGD/R-treated mouse neurons and the effect of m¹A on diverse RNAs. We investigated the m¹A landscape in primary neurons, identified m¹A-modified RNAs, and found that OGD/R increased the number of m¹A RNAs. m¹A modification might also affec

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9991057 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature