The circadian control of tryptophan metabolism regulates the host response to pulmonary fungal infections.

ABSTRACT: The environmental light/dark cycle has left its mark on the body's physiological functions to condition not only our inner biology, but also the interaction with external cues. In this scenario, the circadian regulation of the immune response has emerged as a critical factor in defining the host-pathogen interaction and the identification of the underlying circuitry represents a prerequisite for the development of circadian-based therapeutic strategies. The possibility to track down the circadian regulation of the immune response to a metabolic pathway would represent a unique opportunity in this direction. Herein, we show that the metabolism of the essential amino acid tryptophan, involved in the regulation of fundamental processes in mammals, is regulated in a circadian manner in both mu

SUBMITTER: Stincardini C 

PROVIDER: S-EPMC9991457 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature