Telomeres are shorter in wild Saccharomyces cerevisiae isolates than in domesticated ones.

ABSTRACT: Telomeres are ribonucleoproteins that cap chromosome-ends and their DNA length is controlled by counteracting elongation and shortening processes. The budding yeast Saccharomyces cerevisiae has been a leading model to study telomere DNA length control and dynamics. Its telomeric DNA is maintained at a length that slightly varies between laboratory strains, but little is known about its variation at the species level. The recent publication of the genomes of over 1,000 S. cerevisiae strains enabled us to explore telomere DNA length variation at an unprecedented scale. Here, we developed a bioinformatic pipeline (YeaISTY) to estimate telomere DNA length from whole-genome sequences and applied it to the sequenced S. cerevisiae collection. Our results revealed broad natural telomere DNA length

SUBMITTER: D'Angiolo M 

PROVIDER: S-EPMC9991508 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature