A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo.

ABSTRACT: The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. The sensor (GdL₁) has high selectivity for copper ions and exhibits a 43% increase in r₁ relaxivity (20 MHz) upon binding to 1 equiv of Cu²⁺ in aqueous buffer. Interestingly, in the presence of physiological levels of human serum albumin (HSA), the r₁ relaxivity is amplified further up to 270%. Additional spectroscopic and X-ray absorption spectroscopy (XAS) studies show that Cu²⁺ is coordinated by two carboxylic acid groups and the single amine group on an appended side chain of GdL₁ and forms a ternary complex with HSA (GdL₁-Cu²⁺-HSA). T

SUBMITTER: Paranawithana NN 

PROVIDER: S-EPMC9991518 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature