Extracellular vesicles from human Fallopian tubal fluid benefit embryo development in vitro.

ABSTRACT:

Study question

Do extracellular vesicles (EVs) from human Fallopian tubes exert an influence on early embryo development in vitro?

Summary answer

Human Fallopian tube EVs carrying miRNAs increase murine embryo viability in vitro.

What is known already

Oviductal EVs (oEVs) are recently identified key players in embryo-oviduct interactions that contribute to successful pregnancy in vivo. Their absence in current in vitro systems may partly explain the suboptimal embryo development observed; therefore, further knowledge is needed about their impact on early embryos.

Study design size duration

The oEVs were isolated from the luminal fluid of human Fallopian tubes using ultracentrifugation. We cocultured oEVs with murine two-cell embryos

SUBMITTER: Li Y 

PROVIDER: S-EPMC9991590 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature