TIMSCONVERT: a workflow to convert trapped ion mobility data to open data formats.

ABSTRACT:

Motivation

Advances in mass spectrometry have led to the development of mass spectrometers with ion mobility spectrometry capabilities and dual-source instrumentation; however, the current software ecosystem lacks interoperability with downstream data analysis using open-source software and pipelines.

Results

Here, we present TIMSCONVERT, a data conversion high-throughput workflow from timsTOF Pro/fleX mass spectrometer raw data files to mzML and imzML formats that incorporates ion mobility data while maintaining compatibility with data analysis tools. We showcase several examples using data acquired across different experiments and acquisition modalities on the timsTOF fleX MS.

Availability and implementation

TIMSCONVERT and its documentation can be found at https://

SUBMITTER: Luu GT 

PROVIDER: S-EPMC9991885 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature