Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.

ABSTRACT: Treatment of chronic myeloid leukemia has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines based on numerous clinical trials are available for chronic phase disease. However for CML in the blast phase (CML-BP), prognosis remains poor and treatment options are much more limited. The spectrum of treatment strategies for children and adolescents with CML-BP has largely evolved empirically and includes treatment principles derived from adult CML-BP and pediatric acute leukemia. Given this heterogeneity of treatment approaches, we formed an international panel of pediatric CML experts to develop recommendations for consistent therapy in children and adolescents with this high-risk disease based on the current literature and national sta

SUBMITTER: Sembill S 

PROVIDER: S-EPMC9991904 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature