Integrated cardio-behavioral responses to threat define defensive states.

ABSTRACT: Fear and anxiety are brain states that evolved to mediate defensive responses to threats. The defense reaction includes multiple interacting behavioral, autonomic and endocrine adjustments, but their integrative nature is poorly understood. In particular, although threat has been associated with various cardiac changes, there is no clear consensus regarding the relevance of these changes for the integrated defense reaction. Here we identify rapid microstates that are associated with specific behaviors and heart rate dynamics, which are affected by long-lasting macrostates and reflect context-dependent threat levels. In addition, we demonstrate that one of the most commonly used defensive behavioral responses-freezing as measured by immobility-is part of an integrated cardio-behavioral micr

SUBMITTER: Signoret-Genest J 

PROVIDER: S-EPMC9991919 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature