Methodology and design of platform trials: a meta-epidemiological study.

ABSTRACT:

Objectives

Adaptive platforms allow for the evaluation of multiple interventions at a lower cost and have been growing in popularity, especially during the COVID-19 pandemic. The objective of this review is to summarize published platform trials, examine specific methodological design features among these studies, and hopefully aid readers in the evaluation and interpretation of platform trial results.

Methods

We performed a systematic review of EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov from January 2015 to January 2022 for protocols or results of platform trials. Pairs of reviewers, working independently and in duplicate, collected data on trial characteristics of trial registrations, protocols, and publications of pla

SUBMITTER: Pitre T 

PROVIDER: S-EPMC9991927 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature