Epitope-Specific IgE at 1 Year of Age Can Predict Peanut Allergy Status at 5 Years.

ABSTRACT:

Background

Currently, there is no laboratory test that can accurately identify children at risk of developing peanut allergy. Utilizing a subset of children randomized to the peanut avoidance arm of the LEAP trial, we monitored the development of epitope-specific (ses-)IgE and ses-IgG4 from 4-11 months to 5 years of age.

Objective

The aim of the study was to evaluate the prognostic ability of epitope-specific antibodies to predict the result of an oral food challenge (OFC) at 5 years.

Methods

A Bead-Based Epitope Assay was used to quantitate IgE and IgG4 to 64 sequential (linear) epitopes from Ara h 1-3 proteins at 4-11 months, 1 and 2.5 years of age in 74 subjects (38 of them with a positive OFC at 5 years). Specific IgE (sIgE) to peanut and component proteins was me

SUBMITTER: Grinek S 

PROVIDER: S-EPMC9991938 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature