Familial aggregation of stillbirth: A pedigree analysis of a matched case-control study.

ABSTRACT:

Objective

To determine whether stillbirth aggregates in families and quantify its familial risk using extended pedigrees.

Design

State-wide matched case-control study.

Setting

Utah, United States.

Population

Stillbirth cases (n = 9404) and live birth controls (18 808) between 1978 and 2019.

Methods

Using the Utah Population Database, a population-based genealogical resource linked with state fetal death and birth records, we identified high-risk pedigrees with excess familial aggregation of stillbirth using the Familial Standardised Incidence Ratio (FSIR). Stillbirth odds ratio (OR) for first-degree relatives (FDR), second-degree relatives (SDR) and third-degree relatives (TDR) of parents with a stillbirth (affected) and live birth (unaffected) were esti

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC9991941 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature