Incidence of Pediatric Celiac Disease Varies by Region.

ABSTRACT:

Introduction

The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010.

Methods

Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study screening for tissue transglutaminase antibodies and then CD evaluation per clinical care. Population-specific estimates were calculated by weighting the study-specific cumulative inciden

SUBMITTER: Stahl M 

PROVIDER: S-EPMC9991947 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature