Molecular Subtypes of Head and Neck Cancer in Patients of African Ancestry.

ABSTRACT:

Purpose

The purpose of this study was to better understand the complex molecular biomarkers and signatures of head and neck cancer (HNC) among Black patients and identify possible molecular changes associated with HNC disparities.

Experimental design

Molecular subtypes and genomic changes in HNC samples from patients of African and European ancestry in The Cancer Genome Atlas, Memorial Sloan Kettering Cancer Center, Broad Institute, MD Anderson Cancer Center, and John Hopkins University were identified. Molecular features (genomic, proteomic, transcriptomic) associated with race and genomic alterations associated with clinical outcomes were determined. An independent cohort of HNC tumor specimens was used to validate the primary findings using IHC.

Results

Black patie

SUBMITTER: Mezghani N 

PROVIDER: S-EPMC9991972 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature