Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish.

ABSTRACT:

Background

Homeobox transcription factor encoding genes, genomic screen homeobox 1 and 2 (gsx1 and gsx2), are expressed during neurodevelopment in multiple vertebrates. However, we have limited knowledge of the dynamic expression of these genes through developmental time and the gene networks that they regulate in zebrafish.

Results

We confirmed that gsx1 is expressed initially in the hindbrain and diencephalon and later in the optic tectum, pretectum, and cerebellar plate. gsx2 is expressed in the early telencephalon and later in the pallium and olfactory bulb. gsx1 and gsx2 are co-expressed in the hypothalamus, preoptic area, and hindbrain, however, rarely co-localize in the same cells. gsx1 and gsx2 mutant zebrafish were made with TALENs. gsx1 mutants exhibit stunted grow

SUBMITTER: Coltogirone RA 

PROVIDER: S-EPMC9992111 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature