Tissue-Targeted Drug Delivery Strategies to Promote Antigen-Specific Immune Tolerance.

ABSTRACT: During autoimmunity or organ transplant rejection, the immune system attacks host or transplanted tissue, causing debilitating inflammation for millions of patients. There is no cure for most of these diseases. Further, available therapies modulate inflammation through nonspecific pathways, reducing symptoms but also compromising patients' ability to mount healthy immune responses. Recent preclinical advances to regulate immune dysfunction with vaccine-like antigen specificity reveal exciting opportunities to address the root cause of autoimmune diseases and transplant rejection. Several of these therapies are currently undergoing clinical trials, underscoring the promise of antigen-specific tolerance. Achieving antigen-specific tolerance requires precision and often combinatorial delivery

SUBMITTER: Rui Y 

PROVIDER: S-EPMC9992113 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature