Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.

ABSTRACT:

Background

While fluoride can have thyroid-disrupting effects, associations between low-level fluoride exposure and thyroid conditions remain unclear, especially during pregnancy when insufficient thyroid hormones can adversely impact offspring development.

Objectives

We evaluated associations between fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.

Methods

We measured fluoride concentrations in drinking water and three dilution-corrected urine samples and estimated fluoride intake based on self-reported beverage consumption. We classified women enrolled in the Maternal-Infant Research on Environmental Chemicals Study as euthyroid (n = 1301), subclinical hypothyroid (n = 100) or primary hypothyroid (n = 107) based on their thyroid hormone levels in

SUBMITTER: Hall M 

PROVIDER: S-EPMC9992168 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature