Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport.

ABSTRACT: The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function. In the circulation, all-trans-retinol bound to the RBP4 protein is transported and sequestered into target tissues for long-term storage. Two membrane receptors that facilitate all-trans retinol uptake from RBP4 have been proposed. While it is well established that the membrane receptor, STRA6, binds to circulatory RBP4 for ROL transport into the eye, the second vitamin A receptor, RBPR2, which is expressed in non-ocular tissues, is less characterized. Based on the structural homology between these two RBP4 receptors, published literature, and from our

SUBMITTER: Radhakrishnan R 

PROVIDER: S-EPMC9992173 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature