Development of A novel ferroptosis-related prognostic signature with multiple significance in paediatric neuroblastoma.

ABSTRACT:

Background

Ferroptosis is an iron-dependent regulated cell death pathway that plays an essential role in the occurrence and development of tumours. Nonetheless, little is known about the impact of ferroptosis-related genes (FRGs) on neuroblastoma.

Methods

Transcriptional profiles and clinicopathological data of neuroblastoma were downloaded from the TARGET and GEO datasets. These were used as the training set and the validation set, respectively. Non-negative matrix factorisation was employed to divide patients with neuroblastoma into distinct ferroptosis clusters. The Cox regression model with LASSO was performed based on the FRGs to construct a multigene signature, which was subsequently evaluated in the testing set. Finally, we analysed the differences in the tumour immun

SUBMITTER: Wang X 

PROVIDER: S-EPMC9992189 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature