The causal role of gastroesophageal reflux disease in anxiety disorders and depression: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown an association between gastroesophageal reflux disease (GERD) and anxiety disorders/depression. However, these evidences may be influenced by confounding factors. Therefore, our study aimed to determine the causal relationship between GERD and anxiety disorders/depression by conducting a bidirectional Mendelian randomization (MR) study.

Methods

We performed a bidirectional MR analysis using summary statistics from genome-wide association studies (GWAS) in European individuals. The inverse-variance weighted (IVW) method was used as the primary analytical method to assess causality. In addition, five additional MR methods [maximum likelihood, MR-Egger, weighted median, robust adjusted profile score (MR-RAPS), and mode-based estimate

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC9992201 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature