Evolution of antibody profiles against SARS-CoV-2 in experienced and naive vaccinated elderly people.

ABSTRACT:

Introduction

The third dose of the COVID-19 vaccine is especially necessary in people over 65 years of age due to their lower immune response.

Methods

We designed a multicentre, prospective observational study including 98 people ≤65 years old who lived in two nursing homes in Valladolid, Spain. One of the groups had previous experience with SARS-CoV-2 (n=68;69.4%) and the other was naïve (n=30;30.6%). We evaluated the response to the three doses of the Comirnaty vaccine and the dynamics of antibodies during 5 consecutive serum samplings: 2 after the first two doses of vaccination, one three months after the first dose, another at 6 months and the last one month after the third dose. IgG antibodies against SARS-CoV-2 S1, RBD and N antigens were analysed.

Results

Both

SUBMITTER: Sanz-Munoz I 

PROVIDER: S-EPMC9992205 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature