Multiplatform molecular analysis of vestibular schwannoma reveals two robust subgroups with distinct microenvironment.

ABSTRACT:

Background

Vestibular schwannoma (VS) is the most common tumour of the cerebellopontine angle and poses a significant morbidity for patients. While many exhibit benign behaviour, others have a more aggressive nature and pattern of growth. Predicting who will fall into which category consistently remains uncertain. There is a need for a better understanding of the molecular landscape, and important subgroups therein, of this disease.

Methods

We select all vestibular schwannomas from our tumour bank with both methylation and RNA profiling available. Unsupervised clustering methods were used to define two distinct molecular subgroups of VS which were explored using computational techniques including bulk deconvolution analysis, gene pathway enrichment analysis, and drug repurpo

SUBMITTER: Landry AP 

PROVIDER: S-EPMC9992225 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature