Preclinical developments in the delivery of protein antigens for vaccination.

ABSTRACT:

Introduction

Vaccine technology has constantly advanced since its origin. One of these advancements is where purified parts of a pathogen are used rather than the whole pathogen. Subunit vaccines have no chance of causing disease; however, alone these antigens are often poorly immunogenic. Therefore, they can be paired with immune stimulating adjuvants. Further, subunits can be combined with delivery strategies such as nano/microparticles to enrich their delivery to organs and cells of interest as well as protect them from in vivo degradation. Here, we seek to highlight some of the more promising delivery strategies for protein antigens.

Areas covered

We present a brief description of the different types of vaccines, clinically relevant examples, and their disadvantages when

SUBMITTER: Hendy DA 

PROVIDER: S-EPMC9992317 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature