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The endogenous repertoire harbors self-reactive CD4⁺ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.

ABSTRACT: The T cell repertoire of healthy mice and humans harbors self-reactive CD4⁺ conventional T (T_conv) cells capable of inducing autoimmunity. Using T cell receptor profiling paired with in vivo clonal analysis of T cell differentiation, we identified T_conv cell clones that are recurrently enriched in non-lymphoid organs following ablation of Foxp3⁺ regulatory T (T_reg) cells. A subset of these clones was highly proliferative in the lymphoid organs at steady state and exhibited overt reactivity to self-ligands displayed by dendritic cells, yet were not purged by clonal deletion. These clones spontaneously adopted numerous hallmarks of follicular helper T (T_FH) cells, including expression of Bcl6 and PD-1, exhibited an elevated pr

SUBMITTER: Lee V

PROVIDER: S-EPMC9992328 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Dataset Information

The endogenous repertoire harbors self-reactive CD4⁺ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The endogenous repertoire harbors self-reactive CD4⁺ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.