Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.

ABSTRACT: Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by dystrophin mutations, leading to the loss of sarcolemmal integrity, and resulting in progressive myofibre necrosis and impaired muscle function. Our previous studies suggest that lipin1 is important for skeletal muscle regeneration and myofibre integrity. Additionally, we discovered that mRNA expression levels of lipin1 were significantly reduced in skeletal muscle of DMD patients and the mdx mouse model. To understand the role of lipin1 in dystrophic muscle, we generated dystrophin/lipin1 double knockout (DKO) mice, and compared the limb muscle pathology and function of wild-type B10, muscle-specific lipin1 deficient (lipin1^Myf5cKO ), mdx and DKO mice. We found that further knockout of lipin1 in dys

SUBMITTER: Jama A 

PROVIDER: S-EPMC9992338 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature