Smoking-induced subgingival dysbiosis precedes clinical signs of periodontal disease.

ABSTRACT: Smoking accelerates periodontal disease and alters the subgingival microbiome. However, the relationship between smoking-associated subgingival dysbiosis and progression of periodontal disease is not well understood. Here, we sampled 233 subgingival sites longitudinally from 8 smokers and 9 non-smokers over 6-12 months, analyzing 804 subgingival plaque samples using 16 rRNA sequencing. At equal probing depths, the microbial richness and diversity of the subgingival microbiome was higher in smokers compared to non-smokers, but these differences decreased as probing depths increased. The overall subgingival microbiome of smokers differed significantly from non-smokers at equal probing depths, which was characterized by colonization of novel minority microbes and a shift in abundant members o

SUBMITTER: Tamashiro R 

PROVIDER: S-EPMC9992395 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature