Genetic architecture of asthma in African American patients.

ABSTRACT:

Background

Asthma is a chronic inflammatory disorder with a strong genetic inheritance. Although more than 100 loci were reported through the genome-wide association study of European populations, the genetic underpinning of asthma in African American individuals remains largely elusive.

Objective

We aimed to identify genetic loci associated with asthma in African American individuals.

Methods

Three cohorts were genotyped at the Children's Hospital of Philadelphia by using the Illumina single-nucleotide polymorphism array platform. Genotype imputation was performed by using the Trans-Omics for Precision Medicine (TOPMed) reference panel, which includes whole genome sequencing data from more than 100,000 individuals. A meta-analysis of 3 Children's Hospital of Philadel

SUBMITTER: Chang X 

PROVIDER: S-EPMC9992439 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature