Salivary IgA subtypes as novel disease biomarkers in systemic lupus erythematosus.

ABSTRACT:

Introduction

Immunoglobulin A (IgA) is the main antibody isotype in body fluids such as tears, intestinal mucous, colostrum, and saliva. There are two subtypes of IgA in humans: IgA1, mainly present in blood and mucosal sites, and IgA2, preferentially expressed in mucosal sites like the colon. In clinical practice, immunoglobulins are typically measured in venous or capillary blood; however, alternative samples, including saliva, are now being considered, given their non-invasive and easy collection nature. Several autoimmune diseases have been related to diverse abnormalities in oral mucosal immunity, such as rheumatoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus (SLE).

Methods

We decided to evaluate the levels of both IgA subtypes in the saliva of SLE p

SUBMITTER: Romero-Ramirez S 

PROVIDER: S-EPMC9992540 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature