Correlation between retinal structure and brain multimodal magnetic resonance imaging in patients with Alzheimer's disease.

ABSTRACT:

Background

The retina imaging and brain magnetic resonance imaging (MRI) can both reflect early changes in Alzheimer's disease (AD) and may serve as potential biomarker for early diagnosis, but their correlation and the internal mechanism of retinal structural changes remain unclear. This study aimed to explore the possible correlation between retinal structure and visual pathway, brain structure, intrinsic activity changes in AD patients, as well as to build a classification model to identify AD patients.

Methods

In the study, 49 AD patients and 48 healthy controls (HCs) were enrolled. Retinal images were obtained by optical coherence tomography (OCT). Multimodal MRI sequences of all subjects were collected. Spearman correlation analysis and multiple linear regression model

SUBMITTER: Hao X 

PROVIDER: S-EPMC9992546 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature