Interleukin-11 in idiopathic pulmonary fibrosis: predictive value of prognosis and acute exacerbation.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with a poor prognosis and unknown aetiology. We have recently clarified the prognostic value of the serum platelet-derived growth factor (PDGF) level in patients with IPF. Interleukin (IL)-11 is a member of the IL-6 family, and in vivo and in vitro studies have suggested that it has profibrotic effects in pulmonary fibrosis. In this study, we investigated the predictive value of the serum IL-11 level in patients with IPF for survival and occurrence of acute exacerbation (AE).

Methods

This retrospective study included 68 patients with IPF diagnosed according to the 2018 guideline. Serum PDGF levels were measured using the Bio-Plex method and serum IL-11 levels using enzyme-linked immune-so

SUBMITTER: Arai T 

PROVIDER: S-EPMC9992571 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature