Cardioprotective medication in Duchenne muscular dystrophy: a single-centre cohort study.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) is a neuromuscular disorder characterised by progressive muscle wasting impacting mobility, ventilation and cardiac function. Associated neuromuscular cardiomyopathy remains a major cause of morbidity and mortality. We investigated the effects of cardioprotective medications [angiotensin-converting enzyme inhibitors (ACE-I), beta-blockers] on clinical outcomes in DMD patients.

Methods

This was a retrospective cohort study (reference: 2021/12469) of DMD patients at a tertiary centre between 1993-2021 screening the electronic records for demographics, comorbidities, medication, disease specific features, echocardiography, hospitalisations, and ventilator use.

Results

A total of 68 patients were identified aged 27.4 (6.6) year

SUBMITTER: Kisel J 

PROVIDER: S-EPMC9992617 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature