Intervention strategies in early childhood to prevent celiac disease-a mini-review.

ABSTRACT: A higher intake of gluten during childhood is associated with increased risk of celiac disease, and the incidence of celiac disease peaks shortly after the time point when associations with higher gluten intake during the second and third year of life occur. Additional environmental factors are most likely necessary for celiac disease to develop. It is hypothesized that gastrointestinal infections increase gut permeability and exposure to gluten. Alternatively, infections may lead to gut dysbiosis and chronic inflammation, with leakage of self-antigens that mimic gluten peptides that leads to an autoimmune-like response. Different gluten interventions to prevent celiac disease have been proposed. Early clinical studies suggested an optimal time point introducing gluten between 4 and 6 mont

SUBMITTER: Andren Aronsson C 

PROVIDER: S-EPMC9992640 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature