Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.

ABSTRACT: Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental and physical health outcomes in adulthood. However, whether these relationships are mediated by the consequences of ELS itself or by other exposures that frequently co-occur with ELS is unclear. To address this question, we carried out a longitudinal study in rats to isolate the effects of ELS on regional brain volumes and behavioral phenotypes relevant to anxiety and depression. We used the repeated maternal separation (RMS) model of chronic ELS, and conducted behavioral measurements throughout adulthood, including of probabilistic reversal learning (PRL), responding on a progressive ratio task, sucrose preference, novelty preference, novelty reactivity, and putati

SUBMITTER: Dutcher EG 

PROVIDER: S-EPMC9992709 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature