Markers of aging: Unsupervised integrated analyses of the human plasma proteome.

ABSTRACT: Aging associates with an increased susceptibility for disease and decreased quality of life. To date, processes underlying aging are still not well understood, leading to limited interventions with unknown mechanisms to promote healthy aging. Previous research suggests that changes in the blood proteome are reflective of age-associated phenotypes such as frailty. Moreover, experimentally induced changes in the blood proteome composition can accelerate or decelerate underlying aging processes. The aim of this study is to identify a set of proteins in the human plasma associated with aging by integration of the data of four independent, large-scaled datasets using the aptamer-based SomaScan platform on the human aging plasma proteome. Using this approach, we identified a set of 273 plasma pr

SUBMITTER: Coenen L 

PROVIDER: S-EPMC9992741 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature