Platelet function studies in myeloproliferative neoplasms patients with Calreticulin or JAK2 ^V617F mutation.

ABSTRACT:

Background

JAK2 ^V617F and Calreticulin (CALR) mutations are the most frequent molecular causes of Phi-negative myeloproliferative neoplasms (MPN). Patients with CALR mutations are at lower risk of thrombosis than patients with JAK2 ^V617F. We hypothesized that CALR-mutated blood platelets would have platelet function defects that might explain why these patients are at lower risk of thrombosis.

Objectives

Our main objective was to explore and compare platelet function depending on the MPN molecular marker.

Methods

We analyzed platelet function in 16 patients with MPN with CALR mutations and 17 patients with JAK2 ^V617F mutation and compared them with healthy controls. None of these

SUBMITTER: Guy A 

PROVIDER: S-EPMC9992751 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature