Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality.

ABSTRACT: Biomarkers developed from DNA methylation (DNAm) data are of growing interest as predictors of health outcomes and mortality in older populations. However, it is unknown how epigenetic aging fits within the context of known socioeconomic and behavioral associations with aging-related health outcomes in a large, population-based, and diverse sample. This study uses data from a representative, panel study of US older adults to examine the relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality. We examine whether recent improvements to these scores, using principal component (PC)-based measures designed to remove some of the technical noise and unreliability in measurement, improve the predictive capability

SUBMITTER: Faul JD 

PROVIDER: S-EPMC9992763 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature