Histamine H₂ receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.

ABSTRACT: Schizophrenia is a serious mental disorder, and existing antipsychotic drugs show limited efficacy and cause unwanted side effects. The development of glutamatergic drugs for schizophrenia is currently challenging. Most functions of histamine in the brain are mediated by the histamine H₁ receptor; however, the role of the H₂ receptor (H₂R) is not quite clear, especially in schizophrenia. Here, we found that expression of H₂R in glutamatergic neurons of the frontal cortex was decreased in schizophrenia patients. Selective knockout of the H₂R gene (Hrh2) in glutamatergic neurons (CaMKIIα-Cre; Hrh2 ^fl/fl) induced schizophrenia-like phenotypes including sensorimotor gating deficits, increased susceptibility to hype

SUBMITTER: Ma Q 

PROVIDER: S-EPMC9992765 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature