Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain.

ABSTRACT: Numerous studies have investigated the impacts of common types of chronic pain (CP) on patients' cognitive function and observed that CP was associated with later dementia. More recently, there is a growing recognition that CP conditions frequently coexist at multiple body sites and may bring more burdens on patients' overall health. However, whether and how multisite CP (MCP) contributes to an increased risk of dementia, compared to single-site CP (SCP) and pain-free (PF), is largely unclear. In the current study, utilizing the UK Biobank cohort, we first investigated dementia risk in individuals (n = 354,943) with different numbers of coexisting CP sites using Cox proportional hazards regression models. We then applied generalized additive models to investigate whether MCP leads to exces

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9992778 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature