Dual red and near-infrared light-emitting diode irradiation ameliorates LPS-induced otitis media in a rat model.

ABSTRACT: Objective: Otitis media (OM) is an infectious and inflammatory disease of the middle ear (ME) that often recurs and requires long-term antibiotic treatment. Light emitting diode (LED)-based devices have shown therapeutic efficacy in reducing inflammation. This study aimed to investigate the anti-inflammatory effects of red and near-infrared (NIR) LED irradiation on lipopolysaccharide (LPS)-induced OM in rats, human middle ear epithelial cells (HMEECs), and murine macrophage cells (RAW 264.7). Methods: An animal model was established by LPS injection (2.0 mg/mL) into the ME of rats via the tympanic membrane. A red/NIR LED system was used to irradiate the rats (655/842 nm, intensity: 102 mW/m², time: 30 min/day for 3 days and cells (653/842 nm, intensity: 49.4

SUBMITTER: Ko YS 

PROVIDER: S-EPMC9992796 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature