"Open Sesame" to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer.

ABSTRACT: Pattern recognition receptors are primitive sensors that arouse a preconfigured immune response to broad stimuli, including nonself pathogen-associated and autologous damage-associated molecular pattern molecules. These receptors are mainly expressed by innate myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells. Recent investigations have revealed new insights into these receptors as key players not only in triggering inflammation processes against pathogen invasion but also in mediating immune suppression in specific pathological states, including cancer. Myeloid-derived suppressor cells are preferentially expanded in many pathological conditions. This heterogeneous cell population includes immunosuppressive myeloid cells that are thought to be associated wi

SUBMITTER: Wang T 

PROVIDER: S-EPMC9992799 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature