Cancer risk in patients with Peutz-Jeghers syndrome in Korea: a retrospective multi-center study.

ABSTRACT:

Background/aims

There have been little research on the cancer risks of patients with Peutz-Jeghers syndrome (PJS) in Korea. We aimed to investigate the clinical features of PJS patients and their cancer incidence rate.

Methods

Patients with PJS from nine medical centers were enrolled. In those patients diagnosed with cancer, data obtained included the date of cancer diagnosis, the tumor location, and the cancer stage. The cumulative risks of gastrointestinal cancers and extra-gastrointestinal cancers were calculated using the Kaplan-Meier method.

Results

A total of 96 PJS patients were included. The median age at diagnosis of PJS was 23.4 years. Cancer developed in 21 of the 96 patients (21.9%). The age of PJS diagnosis was widely distributed (0.9 to 72.4 years). The

SUBMITTER: Kim SH 

PROVIDER: S-EPMC9993101 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature