ApoE Modifier Alleles for Alzheimer's Disease Discovered by Information Theory Dependency Measures: MIST Software Package.
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ABSTRACT:
SUBMITTER: Banman A
PROVIDER: S-EPMC9993164 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
<i>ApoE</i> Modifier Alleles for Alzheimer's Disease Discovered by Information Theory Dependency Measures: MIST Software Package.
Banman Andrew A Sakhanenko Nikita A NA Kunert-Graf James J Galas David J DJ
Journal of computational biology : a journal of computational molecular cell biology 20221102 3
Information theory-based measures of variable dependency (previously published) have been implemented into a software package, MIST. The design of the software and its potential uses are described, and a demonstration is presented in the discovery of modifier alleles of the <i>ApoE</i> gene in affecting Alzheimer's disease (AD) by analyzing the UK Biobank dataset. The modifier genes uncovered overlap strongly with genes found to be associated with AD. Others include many known to influence AD. W ...[more]
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