Evidence of Advanced Pulmonary Vascular Remodeling in Obstructive Hypertrophic Cardiomyopathy With Pulmonary Hypertension.

ABSTRACT:

Background

Elevated mean pulmonary artery pressure (mPAP) is common in patients with hypertrophic cardiomyopathy (HCM) and heart failure symptoms. However, dynamic left ventricular (LV) outflow tract obstruction may confound interpretation of pulmonary hypertension (PH) pathophysiologic features in HCM when relying on resting invasive hemodynamic data alone.

Research question

Do structural changes to the lung vasculature clarify PH pathophysiologic features in patients with HCM with progressive heart failure?

Study design and methods

Clinical data and ultrarare lung autopsy specimens were acquired retrospectively from the National Institutes of Health (1975-1992). Patients were included based on the availability of lung tissue and recorded mPAP. Discarded tissue from

SUBMITTER: Maron BA 

PROVIDER: S-EPMC9993337 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature