Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD.

ABSTRACT:

Background

Bronchodilator responsiveness (BDR) in obstructive lung disease varies over time and may be associated with distinct clinical features.

Research question

Is consistent BDR over time (always present) differentially associated with obstructive lung disease features relative to inconsistent (sometimes present) or never (never present) BDR in tobacco-exposed people with or without COPD?

Study design and methods

We retrospectively analyzed data from 2,269 tobacco-exposed participants in the Subpopulations and Intermediate Outcome Measures in COPD Study with or without COPD. We used various BDR definitions: change of ≥ 200 mL and ≥ 12% in FEV₁ (FEV₁-BDR), change in FVC (FVC-BDR), and change in in FEV₁, FVC or both (ATS-BDR). Using

SUBMITTER: Fortis S 

PROVIDER: S-EPMC9993341 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature