Endogenous Interleukin-10 Contributes to Wound Healing and Regulates Tissue Repair.

ABSTRACT:

Introduction

Interleukin-10 (IL-10) is essential in fetal regenerative wound healing and likewise promotes a regenerative phenotype in adult dermal wounds. However, the role of endogenous IL-10 in postnatal dermal wound healing is not well-established. We sought to determine the function of endogenous IL-10 in murine full thickness excisional wounds that are splinted to prevent contracture and mimic human patterns of wound closure.

Methods

Full-thickness excisional wounds were made in wildtype (WT) and IL-10^-/- mice on a C57BL/6J background (F/M, 8 wk old). In a subset of wounds, contraction was prevented by splinting with silicone stents (stenting) and maintaining a moist wound microenvironment using a semiocclusive dressing. Wounds were examined for re-epithelia

SUBMITTER: Short WD 

PROVIDER: S-EPMC9993344 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature