Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats.

ABSTRACT: Numerous epidemiological studies have found co-morbidity between non-severe traumatic brain injury (TBI) and substance misuse in both civilian and military populations. Preclinical studies have also identified this relationship for some misused substances. We have previously demonstrated that repeated blast traumatic brain injury (rbTBI) increased oxycodone seeking without increasing oxycodone self-administration, suggesting that the neurological sequelae of traumatic brain injury can elevate opioid misuse liability. Here, we determined the chronicity of this effect by testing different durations of time between injury and oxycodone self-administration and durations of abstinence. We found that the subchronic (four weeks), but not the acute (three days) or chronic (four months) duration be

SUBMITTER: Chiariello R 

PROVIDER: S-EPMC9993345 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature